FORMULATION AND EVALUATION OF TOPICAL SUSTAINED RELEASE FILM FORMING GEL OF FLUCONAZOLE
R. Mirajkar*, A. Madgulkar, A. Harne and S. Dhage
ABSTRACT
The aim of the research work was to develop Sustained release topical film forming gel of Fluconazole. The gel containing fluconazole was prepared successfully using polymers hydroxypropylmethylcellulose K4M 2.0 % and Polyvinylpyrrolidone K30 2.0% optimized by 32 full factorial design. The optimized formulation showed drying time of 480 seconds, a release of 77%, tensile strength of 0.0614 and antifungal activity of 97.22%. The prepared formulation is effective against the superficial fungal infections and shows its efficacy for cutaneous as well as superficial fungal infections without drug’s invasion into the systemic circulation.
Keywords: Keywords: Film-forming solution, Film-forming system, controlled drug release.
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