Abstract

REVIEW ON: PARKINSON’S DISEASE

Kiran D. Pinjarkar, *Pooja D. Dadmal, Neha D. Chavat, Dipali M. Shende, Rupali H. Chavhan

ABSTRACT

Parkinson’s disease is a neurodegenerative disease of the central nervous system caused due to the loss of dopaminergic neurons. It is classified under movement disorder as patients with parkinsons disease present with tremor, rigidity, postural changes, and a decrease in spontaneous movements. Comorbidities including anxiety, depression, fatigue, and sleep disorders are observed prior to the diagnosis of parkinson’s disease. Gene mutations, exposure to toxic substances, and aging are considered as the causative factors of parkinson’s disease even though its genesis is unknown. This paper reviews Parkinson’s disease etiologies, progression, and in particular measurable indicators of Parkinson’s disease such as neuroimaging and electrophysiology modalities. In addition to gene therapy, neuroprotective, pharmacological, andneural pH transplantation treatments, researchers are actively aiming at identifying biological markers of Parkinson’s disease with the goal of early diagnosis.

Keywords: Parkinson’s disease, Pathology, Genetics, development, Epidemiology.