Abstract

DRUG DIFFUSION THROUGH NAILS/AN UPDATE REVIEW

Vidhi Sharma*, Arsh Chanana, Himmat Singh Chawda and Ravinder Pal Singh

ABSTRACT

Topical drug administration occurs through nails when used as a drug diffusion mechanism. Transungual delivery is another name for the topical delivery of nails. Delivery through the nails helps treat fungal infections and conditions like Onychomycosis, Paronychia, Koilonychia, and Nail Psoriasis, which affect liver toxicity and bioavailability due to first pass effects and different drug combinations. As a treatment for these conditions, doctors may provide medications, immunotherapy, or antifungal creams or pills. The hardness of the nail plate is caused by the keratin cells that make up the nail structure and how they are attached to the nail plate. Nail permeability barriers on the skin. Nail integrity is improved by penetration enhancers. Different technologies, such as mechanical and chemical approaches, have an impact on the effectiveness and simplicity of drug delivery systems that pass through the transungual space. Iontopheresis, medicated ultrasound administration, and pulsed lasers are some of the most recent advances being made to improve nail penetration.

Keywords: Introduction, Anatomy, Disorders, Treatment, Barriers, & Recent Approaches and Techniques.