Abstract

REVIEW ARTICLE ON BRUGADA SYNDROME

Sajja Ravindra Babu, Mehraj Fatima and Balusupati Anjali Venkata Lakshmi*

ABSTRACT

Brugada Syndrome is a rare but serious condition that affects the way electrical signals pass through the heart. The causes include mutation of SCN5A gene most of which are inherited in an autosomal dominant manner from parent to their children. Other causes include structural problem in heart imbalance in chemicals that help send electrical signals through the body. The prevalence of Brugada Syndrome is approximately 3 to 5 per 10,000 people. There are three types of Brugada Syndrome. Risk factors include family history, male, Asians, fever. Dizziness, fainting Gasping and labored breathing, palpitations are symptoms. It is diagnosed with ECG, electrophysiological testing and mapping and Molecular genetic (DNA) testing. Use OTC medications to help bring fever down, stay hydrated. Quinidine, Isoproterenol, Cilostazolare the medications. Device Therapy and Catheter ablation are other procedures for treating Brugada Syndrome. In this article I discuss about the Brugada Syndrome, epidemiology, etiology and pathophysiology, types, risk factors, symptoms, diagnosis and treatment of BrugadaSyndrome.

Keywords: Brugada Syndrome, Molecular genetic (DNA) testing, Quinidine, Device Therapy.