COMPARISON OF EFFECTIVENESS OF ALLOXAN & STRPTOZOTOCIN ON COMPLICATIONS GENERATED FROM DIABETES MELLITUS TYPE-II IN ZEBRA FISH (DANIO RERIO) AS A MODEL
Sunanda Dey and Samrat Bose*
ABSTRACT
Diabetes Mellitus (DM) is one of most important metabolic disease in humans. It’s epidemic from a 21st century. According to the International Diabetes Federation (IDF), in the year 2012, the estimated number of adults living with diabetes had soared to 8.5% of the global adult population. DM is caused by elevated blood sugar level or lack of insulin production or inability of the body to respond to insulin formed in the system. Zebra fish is a small tropical water fish which is now considered as one of the favored animal model system for studying human diseases and other developmental processes as it has greatest advantage of the zebrafish. Alloxan is a urea derivative which in turn causes selective necrosis from the β- tissue of pancreatic islets. Streptozotocin is structurally similar to glucose and N-acetyl
glucosamine.
Keywords: Diabetes Melitus, Alloxan, Streptozotocin, Beta-cell.
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