HPLC METHOD DEVELOPMENT AND VALIDATION OF KETOROLAC TROMETHAMINE: AN OVERVIEW
Faiz Waris*, Dr. Jitendra Kumar Malik and Surendra Pratap Singh
ABSTRACT
Anti-inflammatory drugs that aren't steroids The anti-inflammatory drug ketorolac tromethamine (KT) is a derivative of heteroaryl acetic acid. Nonselective cyclooxygenase (COX) inhibitor, and this is the racemate form of it. Maintaining a therapeutically effective and non-toxic concentration of the medication in the blood or tissues is a major objective of any pharmacological treatment strategy. This is a primary objective of pharmaceutical treatment. In order to be successful, drug treatment programmes need to prioritise this goal. In the past quarter of a century, there have been enormous advances in the controlled delivery of drugs. These advancements are directly responsible for the
increased commercial success of some medications that were reformulated as sustained release delivery systems. Several therapies have received lengthy patent protections as a direct consequence of their success. KT, a nonsteroidal anti-inflammatory drug, works very well. This medicine may be used orally by dissolving it in water. We have discussed the basics of chemometry and its uses in the refinement and verification of HPLC methods. It also addresses the critical data it generates from the reported tests.
Keywords: Ketorolac Tromethamine, HPLC method, LC-MS/MS Determinations, Ultra Performance Liquid Chromatography (UPLC).
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