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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.485

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

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Abstract

PREPARATION AND EVALUATION OF TRANSDERMAL PATCHES OF RANITIDINE

S. Varalaxmi*, Anna Balaji, M. Sailaja, D. Sreeja and K. C. S. Anupriya

ABSTRACT

The proposed work was investigated for preparation and evaluation of transdermal patches of H2 receptor antagonist Ranitidine HCL. The hydrophilic polymer HPMC E15 was selected as polymer and 30 %w/w propyleneglycol was used as plasticizer as well as penetration enchancer for fabrication of patches. Totally four formulations were prepared by varying the percentage of polymer. The prepared formulations were evaluated for their physical integral parameters like surface pH, thickness, weight, percentage moisture loss, percentage moisture absorption, water vapor transmission rate, swelling percentage, folding endurance, drug content and invitro drug release studies. According to the mathematical approach the drug release followed zero order release kinetics from the polymer.

Keywords: Ranitidine HCl, Transdermal patches, Propylene glycol, Plasticizer, penetration enhancer.

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