Abstract

FORMULATION AND IN VITRO EVALUATION OF NIOSOMAL DRUG DELIVERY SYSTEM OF QUININE SULPHATE

M. Hari Sankerji*, R. Archana, E. Giffrin Dona and K. Gokul

ABSTRACT

Quinine sulphate is the antimalarial drug used to treatment for Malaria. Subjugated inherent defects associated with convention dosage form of quinine sulphate such as severe side effects like chest pain, jaundice, abdominal pain, blurred vision, nausea. Niosomal drug delivery system of Quinine sulphate by thin film hydration method by using cholesterol and various non-ionic surfactant such as span 60, span 20 at different ratio (1:1, 1:2), then it was evaluated for various parameters. By formulating oral quinine sulphate niosomes to overcome, Reduce the dose and dose frequency, Minimize the side effects, Prolong the action of drugs, Provide sustained drug release, better patient compliance.

Keywords: Niosomes, quinine sulphate, cholesterol, span 60 or span 20.