Abstract

SCREENING OF METHANOL EXTRACT OF ARGEMONE MEXICANA ROOTS FORINVITRO ANTI-INFLAMMATORY ACTIVITY

Sudhir Singh Gangwar*, Mudit Kumar and Amita Tilak

ABSTRACT

The main objective of the work was to evaluate the use of Argemone mexicana (AM) roots for safety and efficacy in the treatment of inflammation. Methanol extract of roots of Argemone mexicana (Family: Papaveraceae) was assessed for its anti-inflammatory activity by invitro methods. Invitro anti-inflammatory activity was evaluated using albumin denaturation assay, proteinase inhibitory activity at different concentrations. Aspirin was used as standard drug. The results showed that Argemone mexicana Methanol Extract of roots at a concentration range of 100-500μg/ml significantly (p<0.01) protects the heat induced protein denaturation. At the concentration of 400 and 500 μg/ml, AMME showed significant (p<0.01) inhibition of 41 and 51% of proteinase inhibitory action, but at the concentration of 100 and 200 μg/ml did not show significant (p>0.05) activity. The results obtained in the present study indicate that methanol extracts of Argemone mexicana roots can be a potential source of anti-inflammatory agents.

Keywords: Antiinflammatory, Argemone mexicana, invitro, albumin denaturation, Antiproteinase action.