Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS MAY ISSUE PUBLISHED
  • MAY 2020 Issue has been successfully launched on 1 May 2020.

Abstract

HYPOLIPIDEMIC ACTIVITY OF NANOPARTICLES CONTAINING LOVASTATIN IN HYPERCHOLESTERIC ALBINO RATS

Anilkumar J. Shinde,* Harinath N. More

*Department of Pharmaceutics, Bharati Vidyapeeth, College of Pharmacy, Near chitranagari, Kolhapur. India.

ABSTRACT

The present study was carried out to study the effect of nanoparticle formulation on serum lipids in albino rats. The hypolipidemic effect was compared with a standard dose of lovastatin, control and hyperlidemic control group. The rats were divided into four groups of six animals each., viz., test treatment group (TTG), reference treatment group (RTG), control treatment group (CTG) and hyperlidemic treatment group(HTG). The treatment was given for 21 days. Each treatment group received daily standard cholesterol diet, orally in the morning throughout 21 days to induce hyperlipidemia except control treatment group. Test formulation (TF), aqueous suspensions of lovastatin (RF) administered oral dose was 1 mg per animal once a day (equivalent to 10 mg kg–1 per day). Blood samples were collected at predetermined time intervals viz., before treatment and after 5, 10, 15 and 21 days and serum cholesterol, triglycerides and high density lipoproteins were measured. Serum levels on days 10 and 21 were compared using students paired t-test (p < 0.001). The results shows that plasma CH and TG levels were significantly lower (91.70±0.04 mg/dl, 145.50±0.03 mg/dl respectively) (p < 0.001) and HDL-CH levels were significantly higher (44.65±0.02 mg/dl, p< 0.001) in TTG compared to RTG. There was a significant decrease in serum cholesterol in nanoparticle formulation than standard drug.

Keywords: Cardiovascular diseases, Lovastatin formulation, Hypolipidemic drug, Serum Cholesterol.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More