Abstract

A REVIEW ON NEPHROTOXICITY CAUSED BY ANTI-CANCEROUS DRUG

Shubhi Varshney*, Nirbhay Narayan Tiwari, Sheetal Saini and Alankrita Sonkar

ABSTRACT

Nephrotoxicity happens when kidney don't work as expected because of the obliteration in kidney work by exogenous or endogenous harmful substance. Kidney toxicity is a common side effect of drug exposure, as the kidneys are the body's major control system for maintaining homeostasis and are thus particularly vulnerable to xenobiotics. The harmful mechanisms of nephrotoxicity provide valuable knowledge for the development of therapeutic medicines. Changes in blood hematopoiesis, tubular toxicity, and inflammation are all examples of drug-drug toxicity. Renal diseases are common now days because the increase in use of several nephrotoxic drugs like aminoglycosides, analgesic etc. Many diseases like Diabetes and Hypertension also contributing to kidney diseases. The phytoconstituents of some plants are claimed to be useful in prevention of nephrotoxicity. The good sources of these phytochemicals are leaves of Aegle marmelos (Bael), gel of aloe barbadensis (aloe vera) and leaves of Morus nigra (black mulberry) which has antioxidant property that can be useful in nephroprotection. Hence this study was designed to investigate the nephroprotective potential of Aegle marmelos, Morus nigra and aloe barbadensis.

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