Abstract

FORMULATION AND EVALUATION OF DOXOFYLLINE LOADED NANOMICEELES OF SOLUPLUS FOR PULMONARY ADMINISTRATION

Bhushan Pradip Patil, Ramakant Sharma*, Shabnam Khan and Rakesh Patel

ABSTRACT

The pulmonary administration of drugs offers advantages over administration by intravenous injection. Drugs can be rapidly absorbed through the pulmonary mucosa, resulting in a rapid onset of action, and avoiding degradation in the gastrointestinal tract and first-pass metabolism in the liver. Targeting to the lung via pulmonary administration offers potential for the development of new drugs. The present study was aimed towards formulating the Doxofylline loaded Soluplus Nanomicelles with polymer Soluplus in different ratios. The nanomicelles so prepared were characterized for its particle size, ζ-potential, XRD, SEM, drug content and drug release rate. The aim of this research was to prepare Polymeric Micelles Nanomicelles containing Doxofylline as dry powder for inhalation. In order to bypass the disadvantages of conventional formulations, nanotechnology-based drug delivery systems for pulmonary administration and pulmonary targeting have been exploited. Soluplus- Doxofylline Polymeric Micelles showed mean size of 70.73nm and Zeta Potential is -8.71. The Drug Entrapment Efficiency is 87.7% and The Drug Loading Capacity is 10%. In-Vitro study reveals the drug release is 44%. Therefore, The Doxofylline-Soluplus Polymeric Nanomicelles could have the significant value in the treatment of Asthama and COPD.

Keywords: Polymeric Nanomicelles, Asthama, COPD, Doxofylline, Film Hydration Technique, Lyophilisation, Dry powder for Inhalation.