Abstract

COMPARATIVE STUDY OF NEOHESPERIDIN DIHYDROCHALCONE ON CHRONIC CEREBRAL ISCHEMIA-PERMANENT AND REPERFUSION-INDUCED ISCHEMIA ON RATS

Tejaswini Pratapagiri* and A. Lalitha Devi

ABSTRACT

Research on Neohesperidin dihydrochalcone (NHDC) is still in its development, hence this study was carried out to examine NHDC's effects in rats when chronic cerebral ischemia was induced using both permanent and reperfusion models. 80mg/kg/day NHDC was administered orally throughout the 21 days study. The Permanent chronic ischemia model was established by permanent occlusion of the Right Common Carotid Artery, while the Reperfusion model was established by occlusion of both the common carotid arteries for an average of 30 minutes followed by permanent reperfusion. The results show a significant betterment in cognition, motor coordination, grip strength, locomotion, and Post-stroke Depression (PSD), including an increase in Total protein, SOD activity, and GSH content, a notable reduction in MDA and NO levels in treatment groups of both the models when compared to the respective disease control groups showing an effective attenuation of the after-effects of cerebral ischemia. The results obtained from this study conclude that NHDC could potentially be an effective treatment for chronic cerebral ischemia – both permanent and reperfusion-induced and also that the reperfusion-induced cerebral ischemia model (representing ischemia after a heart attack) is better suited for acute studies while the permanent occlusion model (representing conditions like carotid stenosis) is better suited for chronic ischemia studies.

Keywords: Neohesperidin Dihydrochalcone, Chronic cerebral ischemia, Reperfusion, Common carotid arteries, Permanent occlusion, Post-stroke Depression (PSD).