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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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Abstract

CHANGES IN ACETYLCHOLINESTERASE ENZYME ACTIVITY IN FRESH WATER FISH LABEO ROHITA (LINN) ON EXPOSURE TO ORGANOPHOSPHORUS INSECTICIDES

Ganesh Konda*

ABSTRACT

The effects of Sublethal concentration of organophosphorus insecticides, Dimethoate, Profonofos and Oxydemetonmethyl on fresh water fish Labio rohita (Linn) were studied. Most of the OP compounds are similar with the ester part of Acetylcholine and they react with the esterase part of the Acetylcholinesterase (AChE) enzyme after entering into the organism. The conversion of Acetyle Choline into acetic acid and choline catalyzed by AChE is considered to be the key reaction in catabolism. A significant elevation in Acetyle Choline content and inhibition in the activity of the AChE was observed in fishes with three organophosphorus (OP) insecticides for 48, 72 and 96 hours. The interaction of OP insecticides with AChE indicate that their inhibitory action is reversible.

Keywords: Acetylcholine, Labio rohita, Insecticides.

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