Abstract

CURCUMIN: RECENT ADVANCES IN DRUG DELIVERY AND CLINICAL APPLICATIONS

Vijaya Lakshmi Raavi*, Tejo Manasa M., P. Esther Rani, Sireesha M., Prathyusha T. and Satya Sri Varalakshmi V.

ABSTRACT

Curcumin is one of the widely known traditional medicine for its protective and therapeutic properties on human diseases and has a wide spectrum of biological and pharmacological activities. It possesses anti-inflammatory, antioxidant, and anticarcinogenic effects are all present in curcumin. Phenolic hydroxy groups, B-diketone moiety, were found in its structure, which was used to contribute to antioxidation. Even though curcumin has been observed to be safe and effective at high dosages in numerous studies, its relative bioavailability is one of the major serious concerns. It has poor solubility in water and it is still unknown if it breaks down into active or inactive metabolites. To increase the solubility, bioavailability, and effectiveness of curcumin, various new drug delivery vehicles have been reported. In this review, we are going to discuss various drug delivery systems of curcumin are liposomes, micellar formulations, nanoparticles, and cyclodextrin inclusion complexes. that have been used to improve the bioavailability and efficacy of curcumin.

Keywords: liposomes, micellar formulations, nanoparticles, and cyclodextrin.