Abstract

REVIEW ON ANALYTICAL METHODS FOR ESTIMATION OF PREGABALIN AND ETORICOXIB IN PHARMACEUTICAL DOSAGE FORM

Mruga Patel* and Kinjal Parmar

ABSTRACT

Pregabalin is 3-isobutyl derivative of gamma-amino butyric acid (GABA) – an inhibitory neurotransmitter. It may beused in the treatment of neuropathic pain, post herpetic neuralgia, and fibromyalgia, among other conditions. It has anticonvulsant, anti-epileptic, anxiolytic and analgesic activity. And chemically known as (3S)-3-(amino methyl)-5- methylhexanoic acid. Etorocoxib belong to the class of highly selective COX-2 inhibitor NSAIDS. It is mostly used for the treatment of pain, arthritic condition including rheumatoid arthritis and osteoarthritis and chemically known as 5-chloro-3- (4-methanesulfonylphenyl)-2-(6-methylpyridin-3-yl) pyridine. Pregabalin IP (75 mg) and Etorcoxib (60 mg) are recommended in a recently approved FDC for the treatment of neuropathic chronic back pain. Pregabalin (PGB) and etoricoxib (ETC) have analytical methods available for separate quantification, however their combination does not yet have an efficient and dependable analytical procedure. Using spectrophotometry and chromatographic techniques, the updating of etoricoxib and pregabalin in pharmaceutical and bulk forms was the main subject of this review. Spectrometric methods for Etoricoxib and Pregabaline alone and in combination include parameter like wavelength, solvent, linearity, regression coefficient, etc. and HPLC method of Etoricoxib and Pregabaline alone andin combination include parameter like wavelength, mobile phase, stationary phase, flow rate etc. HPTLC Etoricoxib and Pregabaline alone include parameter is mobile phase, stationary phase, flow rate.

Keywords: Etoricoxib, Pregabaline, HPLC, UV, HPTLC, LC-MS, Stability method.