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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

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Updated Version

WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

Call for Paper

WJPPS Invited to submit your valuable manuscripts for Coming Issue.

Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2025 Issue has been successfully launched on 1 NOVEMBER 2025.

Abstract

REVIEW ON CLINICAL PHARMACOLOGY OF 5 – FLUOROURACIL – MECHANISM OF ACTION, RESISTANCE, TOXICITY AND CLINICAL USE

Dr. P. Sharmila Nirojini1*, N. K. Bhuvaneshwari, N. Dharsshini, S. Dhivya Bharathi

ABSTRACT

This is exactly the 60th year of 5 – Fluorouracil playing crucial role in cancer chemotherapy. Since its approval on 1962, 5 -FU has developed into a key agent in treating a wide range of tumors, including all gastrointestinal cancers, breast cancers, bladder cancers, head and neck cancers. Additionally, a novel approach to cancer chemotherapy has emerged that uses pharmacomodulation and biochemical modulation of 5-FU to boost therapeutic efficacy.

Keywords: Fluorouracil, Cancer, Chemotherapy, Resistance, Toxicity.

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