Abstract

PROTECTIVE EFFECT OF CORIANDER SATIVUM L. ON CADMIUM INDUCED TOXICITY IN ALBINO RATS

N.Agnel Arul John*, G.Shobana* and K.Keerthana*

ABSTRACT

Background: Cadmium is a environmental and occupational hazard that causes various degree of damage in target cells mainly in the liver and kidney. It is found in drinking water, atmospheric air, and even in food. Objective: The present study has been undertaken to evaluate the protective effect of Coriandrum sativum L in cadmium chloride induced toxicity in albino rats. Methods: Wistar strains of albino rats were used and the experimental animals were divided into five groups each consisted six animals. In experimental design, group I is served as normal control , group II is served as disease control (intraperitoneally administered with cadmium (6mg/kg of bw) as CdCl2 for 15 days). Group III and IV is induced with CdCl2 and aqueous extract of Coriandrum sativum L (100 and 200 mg/kg of bw) . Group V was treated with plant alone. Result: Oral administration of cadmiumas cadmium chloride showed a significant increase in the marker enzymes (Alanine transaminase, Aspartate transaminase, Alkaline Phosphatase, Acid phosphatase) and Cholesterol in serum and Lipid Peroxide in liver tissue. After the treatment with aqueous extract of Coriandrum sativum L of 100,200mg/kg of bw produced a well pronounced protective effect in response to these parameters in cadmium intoxicated rats. The treatment with cadmium caused a concomitant reduction in the enzymatic and non enzymatic antioxidants like Superoxide Dismutase, Catalase, Reduced Glutathione and serum protein respectively, while treatment with aqueous extract of Coriandrum sativum L at the dose levels of 100 and 200mg/kg of bw resulted in the marked improvement in the antioxidants and protein compared to control rats. Conclusion: The above results concludes that the treatment with aqueous extract of Coriandrum sativum L produced a significant protective effect against cadmium-induced toxicity in albino rats.

Keywords: Coriandrum sativum L, metal toxicity, Cadmium, Antioxidant.