Abstract

A COMPREHENSIVE REVIEW ON THE PARKINSON DISEASE AND ITS ANIMAL MODEL

Raju Gautam*, Shikhar Verma, Akash Ved and Prashant Kumar Singh

ABSTRACT

The discovery of numerous clinical subtypes, pathogenic genes, and potential environmental triggers has cast doubt on the idea of "idiopathic" Parkinson's disease (PD) as a single entity. Along with the traditional motor symptoms, non-motor manifestations (such as rapid eye movement sleep disorder, anosmia, constipation, and depression) start to show up at the prodromal/premotor stage of the disease and then develop along with cognitive impairment and dysautonomia as the disease worsens, frequently taking over in the late stages. The most effective research tools for PD pathogenesis are animal models. Genetic PD models have been created as an alternative to the traditional toxin-based ones as a result of the discovery of PD-related genes, but can dopaminergic neuron models in actual animal models accurately reflect the human disease? For the distinct objectives of the various experiments, the choice of an animal model is crucial. We summarise what is known currently about the several in-vivo PD models employed in this review with regard to the sensitivity of the dopaminergic neurons in the midbrain in the pathogenesis of PD.

Keywords: Parkinson’s disease MPTP, 6-OHDA, Animal Model.