Abstract

ASSESSMENT OF EFFICACY OF VIT-D3 IN HYPERTENSIVE PATIENT MANAGEMENT AT TERTIARY CARE HOSPITAL – A COMPARATIVE STUDY

G. Abishek Arvind*, R. Sivasakthi and P. Nithiyan

ABSTRACT

Introduction: Hypertension is major risk factor for cardiovascular diseases in the world, affecting approximately 26% of the adult population. The renin-angiotensin system is playing a role in the regulation of blood pressure. angiotensinogen is converted to angiotensin I by the Renin. The angiotensin converting enzyme converts the Angiotensin I to angiotensin II. This angiotensin II elevated the blood pressure by constriction of small arteries and improve the retention of salt and water. Renin stimulates the synthesis of angiotensin II. Previous studies indicate, 1α, 25-dihydroxy vitamin D reduces the synthesis of renin and Control the hypertension. Aim: To assess the efficacy of Vit-D3 in reduction of blood pressure in hypertensive patients. Methodology: The Prospective, Comparative, observational study was conducted at the KG hospital, Coimbatore with 120 patients for the period of 6 months. Patients included with study criteria. Result: The mean of Baseline systolic blood Pressure was 156.82 mmHg and 139.25 mmHg in Intervention and Control group and diastolic blood Pressure was 89.49 mmHg and 88.40 mmHg in Intervention and Control group. After follow up, the mean of SBP was found that, 130.82 mmHg and 132.94 mmHg in Intervention and Control group. The mean reduction of DBP in the intervention and Control group was 81.41 mmHg and 78.62 mmHg. Conclusion: The study concludes that, there was a strong relation between 25(OH) D levels and hypertension. The prescription of Vitamin D along with antihypertensive drugs may reduce the blood pressure in hypertensive patients.

Keywords: Blood pressure, Vitamin D, Angiotensin I, Renin, Hypertension.