Abstract

AN INTEGRATED REVIEW ON LIPOSOMES: A NOVEL DRUG DELIVERY SYSTEM

Sufala Rai, Rubeena Khan, Deepshikha Ray, Shyma Khan, Arvind Singh Jadon and Anushree Jain*

ABSTRACT

A liposome is a tiny bubble (vesicle), made out of the same material as a cell membrane. Liposomes can be filled with drugs, and used to deliver drugs for cancer and other diseases. Liposomes are used for drug delivery due to their unique properties. A liposome encapsulates a region on aqueous solution inside a hydrophobic membrane; dissolved hydrophilic solutes cannot readily increase the lipids. Hydrophobic chemicals are able to be dissolved into the membrane, and in this method, liposomes are capable of taking both hydrophobic molecules and hydrophilic molecules. Compared with traditional drug delivery systems, liposomes exhibit better properties, including site-targeting, sustained or controlled release, protection of drugs from degradation and clearance, superior therapeutic effects, and lower toxic side effects. Given these merits, several liposomal drug products have been successfully approved and used in clinics over the last couple of decades. In this review we will discuss about properties, classification, applications and future possibilities of liposomes in pharmaceutical and medical science.

Keywords: Liposomes, Controlled release, Targeted drug delivery, Sustained Release.