Abstract

NASAL DRUG DELIVERY SYSTEM (DRUG RELEASE STUDY OF OPTIMIZED ONDANSETRON HYDROCHLORIDE)

Anmol Gaba, Patel Rakesh, Patel Jeevan* and Sharma Ramakant

ABSTRACT

Objective: The goal of all sophisticated drug delivery systems is to deploy medications to specifically targeted parts of the body through a medium that can control the therapy’s administration by means of either a physiological or chemical trigger. That is, the drug delivery system should deliver drug at a rate dictated by the needs of the body over the period of treatment. In Vitro and Ex vivo drug release study of optimized formulation of Ondansetron Hydrochloride In situ Nasal Gel. In situ nasal gel of Ondansetron Hydrochloride was prepared by using cold technique. The mixture was estimated using double beam UV-visible spectrophotometer (Shimadzu® 1700) at 310 nm against reagent blank. In In-Vivo study, the flux calculated was 12.62 mcg/cm 2hr and the permeability coefficient was 1.419× 10-03cm/hr. In Ex Vivo study, the flux calculated was 13.424 mcg/cm2hr and the permeability coefficient was 1.510 × 10-03 cm/hr. The study includes In Vitro and ex vivo drug release study of Ondansetron Hydrochloride in situ Nasal Gel. It can be concluded that the permeability coefficient in Ex Vivo study came out to be more.

Keywords: Spectrophotometrically, Ondansetron, Peptides and Proteins, Vaccines, Bioavailability, Nasal drug delivery.