Abstract

IN-SITU GELS -A NOVEL APPROACH FOR OCULAR DRUG DELIVERY.

Mane Kirti*, Dhole Shashikant

ABSTRACT

Eye is the most important organ of body. The conventional ophthalmic dosage forms consist of 90% of currently available ophthalmic formulations. The major drawback associated with conventional ophthalmic formulations is quick precorneal drug loss resulting in poor bioavailability and therapeutic response, because of high tear fluid turnover and dynamics. Various attempts were made to improve ophthalmic drug bioavailability. In-situ-forming gels are solutions, instilled as drops into the eye and undergo a sol to gel transition in the cul-de-sac thus improved ocular bioavailability by increasing the contact time with corneal tissue, thereby reducing the frequency of administration required in case of conventional ophthalmic solutions, thus optimizing ocular therapy. Lot of novel temperature, pH, and ion induced in-situforming systems has been prepared for sustained ophthalmic drug delivery. Now a days in situ gel have been used as vehicles for the delivery of drugs for both local treatment and systemic effects. The present article describes the formulation and evaluation of an In-situ ophthalmic drug delivery system based on the concept of pH triggered in-situ gelation, temperature dependent in-situ gelation and ion activated in-situ gelation.

Keywords: conventional ophthalmic formulations, precorneal drug loss, in-situ forming gels, in-situ gelation, temperature dependent in-situ gelation and ion activated in-situ gelation