Abstract

EMULGEL OF GABAPENTIN AS TOPICAL DRUG DELIVERY

Tharini L.*, Madhura N., Neethu Kumari K., Mohd Mustafaiz, Nabi Mehabub Alam and Muklesur Hossain

ABSTRACT

The goal of this study was to prepare and evaluate an emulgel system for gabapentin using carbopol 934 (synthetic polymer) and xanthan Gum (natural polymer) as gelling agents. Drug and polymers are mixed to prepare the emulsion and the gel bases were prepared separately by dispersing various polymer concentrations (xanthan gum and carbopol 934) and this is mixed in a ratio of 1:1 to prepare the emulgel. Compatibility studies showed that there were no physical or chemical interaction between drug and excipients. All prepared formulations were evaluated. In terms of physical properties (like colour, homogeneity, consistency) all the prepared formulations were white in colour, smooth consistency and homogenous. pH of all the formulations were in the range 5.8-6.40. Swelling ability of F4 formulation was more compared to other formulations when performed for 30min. Rheological study (viscosity) of prepared emulgels were determined using Brookfield viscometer, F4 formulation exhibited greater viscosity containing natural polymer. Drug content determination studies were performed for all prepared formulations among which F4 exhibited greater drug content and stability studies shows that the prepared emulgel retains it stability upon storage. Among all the prepared formulations optimized formulation was found to be F4 with 90.25% release rate. Therefore, xanthan Gum based formulations has shown better performance than carbopol-934, indicating that natural gelling agent is a better than synthetic gelling agent Carbopol-934.

Keywords: Gabapentin, Emulgel, Xanthum gum, Brookfield viscometer, Franz diffusion cell.