Abstract

STABILITY STUDY OF KHADIRASHTAK KWATHA AND SAPTAVIMSHATI GUGGULU USED IN THE TREATMENT OF ADENOMYOSIS- WITH RESPECT TO BASELINE MICROBIAL DIAGNOSTIC MODALITIES

Sheela Pant*, Vijay Kodiyatar, M. S. Cholera and Laxmipriya Dei

ABSTRACT

Introduction: Globally, the prevalence of adenomyosis is 9% in healthy individuals. Diffuse patterns of adenomyosis are found in 54% of young women with infertility and dysmenorrhea or menorrhagia. In women undergoing assisted reproductive technologies (ARTs), the prevalence of adenomyosis is 20% to 25%. Nationally, the prevalence is found to be 23.5% in patients who had complain of menorrhagia and dysmenorrhea. Patients with adenomyosis usually presents with menorrhagia, dysmenorrhea and infertility, also dyspareunia and increased frequency of micturition due to enlarged and tender uterus. In one-third, it remains asymptomatic. The conventional management of adenomyosis includes the medical management to reduce pain and excessive bleeding by using OC pills, LNG-IUS, NSAIDs etc. as well as surgical management by adenomyomectomy, uterine mass reduction, uterine artery embolization etc. Hysterectomy is done in parous and aged woman. In spite of high cost of therapy, there is no permanent cure. No definite treatment is claimed for adenomyosis till date. There is no direct reference regarding adenomyosis in Ayurveda. It is a type of MamsaDushti due to vitiated Dosha especially Vata and Rakta characterized by Sotha of uterus which give features of Asrigdara, Kastartava and Vandhyatvo. In present study Khadirastaka Kwatha and Saptavimshati Guggulu has been used as oral therapy along with purificatory measures as Khadirastaka Kwatha acts on Rakta Dushti and Saptavimshati Guggulu relieves Sotha and Shoola. Materials and Method: Stability of the drug Khadirastaka Kwatha and Saptavimshati Guggulu with respect to its microbiological profile was carried out. Both the drugs were stored in plastic container during different climatic conditions and were studied at regular intervals for a period of 10 months to analyze mycological & bacteriological findings by Wet mount preparation and Gram stain test respectively. Observation and Result: Till the end of the study, it was evident that there were no any evidence of micro-organisms present in the subjected samples, even in different climate and temperature. Conclusion: Hence, in present study, the stability test of Khadirastaka Kwatha and Saptavimshati Guggulu with respect to its microbiological findings was negative at all climatic conditions like room temperature, warm, cool, dry or humid conditions.

Keywords: Adenomyosis, Khadirastaka Kwatha, Microbial profile, Saptavimshati Guggulu, Stability.