Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE TABLETS OF ACECLOFENAC SODIUM

Pinky Jaiswal*, Mohammad Jalaluddin, Brajesh K. Arjariya, Sheenam Mansuru and Praveen K. Jain

ABSTRACT

The aim of the present investigation was to develop a suitable matrix tablets for sustained release drug delivery of aceclofenac in order to overcome their side effects by conventional dosage form. A total of 10 sustained release tablets were prepared by melt granulation method using Hydrophobic waxes. The formulations were characterized including uniformity of weight, drug content, hardness, thickness, and swelling index to study the stability of the formulations and in vitro dissolution of the experimental formulations were also performed to determine the drug distribution in the matrix. Drug–excipient interaction studies were carried out using Fourier transform infrared (FTIR) spectroscopic technique. Optimized formulations (F 8) were found to be suitable for formulating in development of sustained release matrix tablets in terms of physicochemical characteristics and there was no significant interaction noticed between the drug and blend of waxes used.

Keywords: Aceclofenac, Hardness, Swelling Index, FTIR, Formulation.