Abstract

AN OVERVIEW ON FORMULATION AND EVALUATION OF CIPROFLOXACIN HYDROCHLORIDE FLOATING TABLETS USING NATURAL POLYMERS

Suraj Kumar Sah*, Ms. Anupriya Adhikari, Dr. Shivanand Patil

ABSTRACT

The present study by Formulation and Evaluation of Floating Tablets of Ciprofloxacin HCl as a model drug for prolongation of gastric residence time. Floating tablets were formulated with various materials various materials like xanthangum and Guargum, Chitosan at varying concentration were used for release controlling properties, sodium bicarbonate act as effervescent agent and lactose is used as Diluent. The tablets were prepared by direct compression technique and the prepared tablets remained buoyant for more than 12 hours in the released medium and showed good Bioadhesion Strength. The variant proportion of the polymers Xanthumgum and Guargum, Chitosan showed significant difference in the release rate, buoyancy, bioadhesive strength and lag of the tablet.

Keywords: Ciprofloxacin HCL, floating bioadhesive tablets, flouroquinolone antibiotic.