Abstract

DESIGN AND EVALUATION OF IN-SITU GELLING SYSTEM OF AN ANTI-DIABETIC DRUG FOR PROLONGED RELEASE BY SIMPLE MIXING METHOD

Susanna Siwakoti*, Dr. Sowjanya Battu and B.A. Viswanath

ABSTRACT

Gel dosage forms are utilised as drug delivery systems to control or modify drug release and protect medications from a hostile environment with great effectiveness and success. In-situ gels, which can be supplied by oral, vaginal, injectable, ophthalmic and intraperitoneal routes are hydrogels that are in the form of solutions that undergo gelation in contact with body fluids or change in pH and temperature. The oral route is the preferred and most often used method of medication delivery. Metformin hydrochloride, a BCS Class-III anti-diabetic medicine, was developed as an oral in-situ gel dosage form with a primary goal of increasing bioavailability as a convenient dose form. An overview of the developed oral in-situ gel drug delivery system is provided in this review paper. However, the main purpose of this review is to provide furthermore advancement and techniques that will make an ease and effective formulation.

Keywords: Oral in-situ gel, Metformin Hydrochloride, Diabetes mellitus, Polymers