Abstract

SOLUBILITY AND BIOAVAILABILITY ENHANCEMENT OF POORLY WATER-SOLUBLE ANTIDIABETIC DRUG BY SOLID DISPERSION TECHNIQUE USING MICROWAVE IRRADIATION

Prashant Sagar Bhatta*, Dr. Sowjanya Battu and B.A. Viswanath

ABSTRACT

Within the various formulations, solid dispersion technique has proved most successful, convenient and more economical in improving solubility and bioavailability of very poorly water soluble oral antidiabetic drugs like Glipizide, Gliclazide, Glyburide. The basic concept behind the development of oral Solid dispersions system is to increase pharmacokinetic followed by pharmacodynamic of drug molecules by using different approaches. Different methods have already been developed with the intention of formulation of the solid dispersions and these methods mainly deals with the challenges of mixing a matrix i.e polymers and Active drugs. During the formulation, formation of different phases, poor solubility and other challenges has been widely observed in past research works, So the main objective of this article is to provide better understanding of how the uniform solid dispersion can be made using microwave irradiations with optimized hydrophilic polymers like Hydroxy propylmethyl cellulose, polyethylene glycols and how the oral solid dispersion of antidiabetic drug get absorbed and shows their action to treat the disease like diabetes (type 2). Various types of oral solid dispersions as well as its benefits and faults has been discussed. So this review article is the overview of the methods using instrument like microwave that provides better mixing of polymers and active drugs and various hydrophilic polymers that are either used as carriers or controlled delivery component for the solid dispersion.

Keywords: Solid dispersion, Microwave irradiations, Glipizide, Oral drug delivery.