Abstract

VALIDATION OF ANALYTICAL METHODS FOR ESTIMATION OF ESOMEPRAZOLE IN PHARMACEUTICAL DOSAGE FORMS - A REVIEW

C. Saravanan*, M. Manivasagan, M. Manojkumar and K. Kaveri

ABSTRACT

Esomeprazole is used to treat condition where there is too much acid in the stomach. It is used to treat duodenal and gastric ulcers, erosive esophagitis, Gastro Esophageal Reflux Disease (GERD), and Zollinger-Ellison syndrome, a condition wherein the stomach produces too much acid. In the pharmaceutical industry, analytical method development gives important information of drugs potency, bioavailability and its stability. Analytical methods have been report for various studies in analysis of product. So far, around Thirty Seven analytical methods have been reported for various studies on analysis of esomeprazole in bulk, pharmaceutical formulations and biological fluids, tablets, and capsule. This review highlights different analytical methods such as chromatography, spectroscopy, and hyphenated techniques of esomeprazole. These techniques are either explored for the quantification, detection of metabolite and also for stability-studies of the esomeprazole. The present studies revealed that HPLC techniques along with spectroscopic have been most widely explored for the analysis. The brief review may provide information to the researchers who are working in the area of analytical research of esomeprazole.

Keywords: Esomeprazole, Analytical methods, HPLC, HPTLC, LCMS, GCMS, UPLC, TLC, UV-Spectroscopy, Infra-red spectroscopy, NMR Spectroscopy.