Abstract

DEVELOPMENT AND EVALUATION OF FLOATING TABLETS FOR GASTRIC RETENTION USING SILYMARIN AS A MODEL DRUG

Anish Kumar Yadav*, G. N. Mythily, Sowjanya Battu and Girindra Lekhi

ABSTRACT

In the present research work gastro retentive floating matrix formulation of Silymarin by using various polymers were developed. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimised. Then the formulation was developed by using different concentrations of polymers Ethyl cellulose, HPMC K4M, Sodium CMC and Carbopol P934 as polymeric substances. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the formulations HPMC K4M as polymer were retarded the Maximum drug release until 12 hours (F5=98.15%). whereas in low concentrations the polymer was unable to produce the desired action. The optimized formulation dissolution data was subjected to release kinetics, from the release kinetics data it was evident that the formulation followed peppas release kinetics mechanism of drug release.

Keywords: Silymarin, Ethyl cellulose, HPMC K4M, Sodium CMC, Carbopol P934, Floating Tablets.