Abstract

SPRAY DRYING TECHNIQUES IN THE FORMULATION OF PHARMACEUTICAL DOSAGE FORMS

Vinutha Naik*, Krishnananda Kamath K. and A. R. Shabaraya

ABSTRACT

Spray drying is a method of changing a dry powder from a liquid or slurry by rapidly drying with a hot gas. This is the preferred method of drying of many thermally sensitive food and pharmaceuticals or materials which may require extremely consistent fine particle size. Spray drying technique uses a one-step process for formation and drying of powders. Using this technique the number of unit operations is reduced, improving production efficiency and reducing costs, especially since spray drying is a technique which can be easily automated and equipped for in-line product analysis. In addition, spray drying can be considered a continuous process, thus reducing time-to-market because of scale-up benefits and better quality. Spray drying has a wide range of applications in the pharmaceutical and biotech industry. Spray drying is applied to improve the compatibility of drugs and to perform microencapsulation, granulation and complex formation. In addition, spray drying is successfully used for the modification of biopharmaceutical properties and the formulation of dry powder aerosols and heat sensitive materials.

Keywords: Spray drying, Encapsulation, Heat sensitive materials, Nanoparticles.