Abstract

PRONIOSOMES: A NOVEL DRUG DELIVERY CARRIER

Shubham Yadav* and Santosh Kumar Rada

ABSTRACT

The basic goal of drug therapy is to deliver a medication's therapeutic action to a specific location inside the body quickly and control the desired drug amount to provide the preserved effect. The essential drug distribution in non-targeted tissues and body liquids necessitated remedial dosages that could greatly surpass the necessary amount in targeted cells and the stronger dosage typically led to harmful health during and after treatments. Standard pharmaceutical dosage forms are unable to control the delivery rate of drugs to the specific target site. One such method is the vesicle-based drug delivery system, which includes niosomes, proniosomes, liposomes, and pharmocosomes, among others, and serves to extend the drug duration in pulmonary circulation and reduces toxicity. Niosomes have caught attention as drug-targeting agents and carriers to address the drawbacks of liposomes and proliposomes. In comparison to the traditional dosage form, this article compares the benefits and drawbacks of vesicular drug delivery, Proniosomes definition, its kinds, and its method and uses. Any substrate utilised for drug delivery is referred to as a drug carrier. A suitable drug carrier that aims to increase the selectivity, efficacy, and safety of medication administration is the fundamental part of the drug delivery system. Proniosomes are so prospective drug carriers that are non-ionic surfactant-based uni-lamellar or multi-lamellar vesicles that are currently used in place of liposomes because of their biocompatible, biodegradable, and non-immunogenic composition. They share a bilayer structure with liposomes and are comparable structurally, however Proniosomes are more stable due to chemical changes in the monomer units. Both hydrophilic as well as lipophilic drugs can be trapped by them in the vesicular membrane or an aqueous layer. Proniosomal carriers are appropriate for the transdermal distribution of the wide range of pharmacological drugs, comprising antioxidant, anticancer, anti-inflammatory, antimicrobial, and antibacterial compounds.

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