Abstract

CASE REPORT ON CYPROHEPTADINE INDUCED SEIZURES

Indana Manvitha*, Muvvala Sudhakar, Yadala Shravani, Bheema Sai Suyagna, Shaik Nazma and Janvi Varma

ABSTRACT

Cyproheptadine is a first generation antihistamine which is used as histamine antagonists and also as an appetite stimulant. Antagonism of serotonin on the appetite centre of hypothalamus may account for Cyproheptadine’s ability to stimulate appetite. A 28 year old female patient was admitted in general medicine department with chief complaints of sudden onset of involuntary movements of both upper limbs since last night, up rolling of eye, tightness of jaw for 10 minutes and also presented with 2-3 episodes of seizures. She was not a known case of Hypertension, Diabetes Mellitus, Asthma, Arthritis and was healthy so far. She was presented with loss of appetite 2 months back to a local Registered Medical Practitioner. Her past medication history includes Dexamethasone and Cyprohetadine for stimulating appetite since 2 months. Upon admission patient was conscious and coherent and responding to oral commands, on examination facial fluffiness was observed and physician diagnosed the condition as drug induced seizure. Prolonged usage of cyproheptadine leads to seizures as the patient had lean body mass and increase in fress drug concentration. Symptomatic treatment was given to the patient with antiepileptic drugs. So there is a need of evidence based medicine in the use of appetite stimulants.

Keywords: Drug induced seizures, Cyproheptadine, Appetite stimulant.