Abstract

DEGRADATION STUDY OF DIFFERENT BRANDS OF ANTIPYRETIC TABLETS BY UV SPECTROSCOPY

Umesh Rangat*, Anjan Ladage, Bharatee Chaudhari and Vivekkumar Redasani

ABSTRACT

In the present project forced degradation study of different brands of Paracetamol Tablets were performed. Forced degradation of drug substance was performed by exposing it to Acid, Base, and UV light. The amount of degradation product can be determined with the help of UV spectrophotometer. Forced degradation of drug substance of Pacimol, Pyrigesic and Calpol were observed. In the result negligible difference was observed on exposure to UV. This method can be used successfully for studying the stress degradation factors. Because this method is less time consuming and simple and cost effective. Three different Brands that is Pacimol, Pyrigesic and Calpol of Paracetamol Tablets were used for the study. It was found that very negligible degradation was occurred.

Keywords: UV spectroscopy, Paracetamol, UV Cabinate, Acid Degradation, Base Degradation.