Abstract

EFFECT OF AGE, BODY MASS INDEX, AND DURATION OF DISEASE ON CHYMASE AND ANGIOTENSIN II FOR PATIENTS WITH TYPE 2 DIABETES MELLITUS

Sattar Gaber Hassan*, Shaymaa Zahraw Nada and Firas Shawqi Algburi

ABSTRACT

Diabetes mellitus(DM) is a metabolic disease with the mean characteristic is hyperglycemia resulting from defects in insulin action, insulin secretion, or insulin resistance, it always is jointed with long-term harm, dysfunction, and failure of organs, particularly the heart, nerves, eyes, kidneys, and blood. Objective:- This study aims to investigate the effect of gender, duration of disease, body mass index, and age groups on the values of the studied variables with other parameters in patients and healthy subjects. Subjects and Method:- A case-control study of individuals with type 2 diabetes was conducted from November 2021 to May 2022. This study was conducted on 62 patients with type 2 diabetes who attended Imam Hussein Medical City in Karbala. And 28 cases in the control group, and patients were divided into four groups according to body mass index and also they were divided into three groups according to age, as well as they were divided into three groups according to the duration of the disease. Result:- The study of the Comparison between type 2 Diabetes Mellitus for Biochemical Parameters showed In (HDL, LDL, FBS, CHOL, HbA1c, Macroalbuminuria, TG, VLDL, blood urea, serum creatinine, Chymase, and Angiotensin II), there were statistically significant differences between all groups The study revealed a positive linear regression between Chymase and ANGII with age, BMI and duration of disease. Conclusion:- Age, body mass index and disease duration have a direct effect on the levels of chymase and ANG II concentrations. Increased levels of both chymase and ANG II levels play a role in the pathogenesis of diabetic nephropathy.

Keywords: Diabetes mellitus, Chymase, Angiotensin II.