Abstract

FORMULATION AND CHARACTERIZATION OF PHOSPHOLIPID-BASED MIXED MICELLES FOR TOPICAL DELIVERY OF MANGIFERIN

Shalini Devi* and Dr. R. B. Sharma

ABSTRACT

Mangiferin is hydrophobic drug that has been widely researched for its therapeutic activities that include anti-inflammatory, anti-viral, and analgesic, immunomodulatory, anti-oxidant, anti-diabetic and several more. But being a hydrophobic drug the challenge arises in delivering the drug appropriately at the target site. Solubilization of mangiferin is still a challenge in the pharmaceutical industry. This research study indicates the use of phospholipid based mixed micelles as a means to address this issue. The phospholipid mixed micelles system is an important technique to improve the solubility of water-insoluble drugs and the drug can reach at the target site without drug precipitation upon aqueous dilution. The use of phospholipid mixed micelles not only improves the solubility of poorly soluble drug but also provide patient compliance and the drug can effectively show therapeutic activity at target site. Phospholipids were used to make the mixed micelles, which were then tested for drug loading and entrapment efficiency, particle size, zeta potential, protein binding, and MTT assay. The produced micelles were shown to be biocompatible and to have a long-lasting releasing activity. It was concluded that the research findings are positive and provide a foundation for improving the efficacy profile of one of the most extensively used drugs.

Keywords: Mangiferin, hydrophobic drugs, mixed micelles, topical drug delivery, phospholipids, phosphatidylcholine (PC), drug release study, MTT assay.