Abstract

DESIGN, DEVELOPMENT AND CHARACTERIZATION OF BIO-COMPATIBLE CO-DELIVERY SYSTEM FOR ISOTRETINOIN AND CLINDAMYCIN TOPICAL SOLID LIPID NANOPARTICLES

Kiran Kumari*, Twinkle Garg and R. B. Sharma

ABSTRACT

More than 95% of world population suffers from acne vulgaris atleast once in their lifetime. Acne is a multifactorial, inflammatory disease of pilosebaceous unit that affects the skin of face, neck, chest, upper back. This inflammatory disease initially appears during the onset of puberty and is most common in adolescents, but it appears in neonates, adults as well as pre-pubescent children. The androgenic stimulation in males and females triggers the secretion of sebum and follicular keratinization. The hyper proliferation of Propionibacterium acne, and inflammatory response initiated by bacterial antigens and cytokines are responsible for acne. Topical route of drug delivery is always preferable over other routes of delivery especially in case of skin diseases as the drug is directed applied on the targeted site and can effectively treat the disease with high therapeutic efficacy, cost effectiveness and patient compliance. Isotretinoin and clindamycin are used for treatment of acne but alone. In this, a research has been conducted to develop the Solid lipid nanoparticles containing both API and characterized for drug loading and entrapment, particle size, zeta potential, and drug release profile, Protein binding and antibacterial properties. The developed formulation was found effective on all the parameters characterized.

Keywords: Isotretinoin, Clindamycin, Solid Lipid Nanoparticles (SLNs), topical drug delivery, acne vulgaris, carrier based system, biocompatible system.