Abstract

FORMULATION AND EVALUATION OF BILAYER TABLET OF FUROSEMIDE

Ramakant Sharma*, Jeevan Patel and Revathi A. Gupta

ABSTRACT

The goal in designing sustained or controlled delivery systems is to reduce the frequency of the dosing or to increase effectiveness of the drug by localization at the of action, reducing the dose required or providing uniform drug delivery. The primary objective of sustained release drug delivery is to ensure safety and to improve efficacy of drugs as well as patient compliance. For the purpose of enhancement, the bioavailability of furosemide (FR), with controlled release of FR was designed in this study. Because of the low half-life of active material, it was first enhanced by preparing a Bilayer drug delivery system. Also, the formulation is much easier than the other sustained drug delivery systems. The blend and compressed tablet were evaluated for physical characteristics like bulk density, tapped density, angle of repose, hardness, friability, disintegration time and chemical character like in-vitro dissolution, content of uniformity. The stability study was conduct for optimize batch. The major aim of sustained drug delivery is to reduce the frequency of dosing.

Keywords: Bioavailability; Furosemide; Sustained Release; Localization.