Abstract

EVALUATION OF IN VITRO ANTI-ARTHRITIC ACTIVITY OF SAPINDUS MUKOROSSI GARTAN. FRUIT

Priyanka Lande*, Mayuri Pawar, Shivraj Kadam, Mona Agrawal and Yogesh Agrawal

ABSTRACT

The purpose of this study was to determine the anti-arthritic activity of a methanolic fruit pericarp extract of Sapindus mukorossi in vitro (family: Sapindaceae). The plant's methanolic extract was fractionated with n-butanol, n-hexane, chloroform, and ethyl acetate. All fractions/extracts were quantitatively assessed for saponins, total phenolic and flavonoid content, and preliminary phytochemical screening. Further examination of anti-arthritic activity was carried out under controlled experimental circumstances employing various invitro anti-arthritic activity methods such as bovine serum albumin denaturation and egg albumin denaturation. Protein denaturation was determined by measuring its absorbance. The results showed that the plant extract had anti-arthritic action in a concentration-dependent manner, and the activity increased as the concentration of extracts was increased. The present study found that the fruit pericarp of Sapindus mukorossi possesses anti-arthritic action.

Keywords: Anti-arthritic activity, Protein denaturation, Sapindus mukorossi.