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Abstract

RECENT ADVANCES IN GENE THERAPY FOR MAJOR NEUROLOGICAL DISORDERS

Riya D. Bakhtar*, Vedant Malamkar and Sachin J. Dighade

ABSTRACT

Gene therapy is rapidly emerging as a powerful therapeutic strategy for a wide range of neurodegenerative disorder, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD). Some early clinical trials have failed to achieve satisfactory therapeutic effects. Efforts to enhance effectiveness are now concentrating on three major fields, identification of new vectors, novel therapeutic targets, and reliable of delivery routes for transgenes. These approaches are being assessed closely in preclinical and clinical trials, which may ultimately provide powerful treatments for patients. Here, we discuss advances and challenges of gene therapy for neurodegenerative disorders, highlighting promising technologies, targets, and future prospects.

Keywords: Gene therapy, Genetic Vectors, Neurodegenerative disorders, Advances, Genetic therapy.


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