Abstract

NOVEL PERSPECTIVE ON RHINOCEREBRAL MUCORMYCOSIS

Vibhuti Sapru, Tanisha Das, Prapti Chakraborty and Priyanka Ray*

ABSTRACT

Mucormycosis is a potentially fatal illness. It is caused by fungus belonging to the Zygomycetes class and Mucorales order. The immune-compromised hosts are the ones who are most vulnerable to fungal infection. Steroid medication, solid organ transplantation, prolonged corticosteroid therapy, malnutrition, hemochromatosis, HIV patients, neutropenia, hematologic malignancies, and other diseases are frequently linked. The lack of predisposing factors, on the other hand, does not rule out the potential of mucormycosis. A rise in serum iron levels has also been associated to mucormycosis. Mucormycosis is a rapidly developing infection that takes more than antifungal treatment to treat. In the future, certain novel therapies will be necessary. Iron uptake could be a critical stage in the pathogenetic mechanism of the pathogenic organisms. As a result, inhibiting the accumulation of fungal iron could be a promising treatment method for improving clinical outcomes in this devastating disease. This review provides a current state of therapy choices in this review study. Despite the fact that mucormycosis is a rare disease, its consequences are deadly.

Keywords: Mucormycosis, Zygomycetes, diabetic ketoacidosis, iron acquisition, corticosteroid therapy, hemochromatosis, antifungal therapy.