Abstract

AN OVERVIEW CHALCONE AND THEIR BIOLOGICAL ACTIVITY

Pawar Aravind R.*, Chavan Gopinath, Sandeep U., Ramesh G. and B. Shivakumar

ABSTRACT

Chalcones are α,β-unsaturated ketones that can be easily obtained by Claisen-Schmidt condensation between ketones and aromatic aldehydes. Chalcones bearing electron donating or electron withdrawing substitutions were prepared and their glucose uptake activity was evaluated. Some novel heterocyclic derivatives such as Thazines, Oxazines, Isoxazoles and Pyrazoles were synthesized from various Chalcones. A simple method for the synthesis of chalcones is reported using Anhydrous K2CO3 under microwave assisted solid phase, solvent-free method. Green chemistry is also called sustainable chemistry, Microwave-assisted organic synthesis which is an important tool for heating in the organic synthetic reaction. This process is simple, efficient, economical, and environmentally benign compared to classical reactions. The novel chalcone derivatives were prepared by acid-catalyzed one-step condensation of 1,3- or 1,4-diacetylbenzene and 1,3,5-triacetylbenzene with 4-hydroxy-3-methoxy benzaldehyde. chalcones are important compounds in their own right with applications in medicine and physics. All these compounds were screened for anti-fungal, anti-bacterial, and anti-oxidant activity. Cyclohexenone derivatives, in general, showed better anti-fungal and anti-bacterial activity than parent chalcones.

Keywords: Claisen-Schmidt condensation, Green chemistry, Microwave-assisted, solvent-free method.