Abstract

FORMULATION AND EVALUATION OF ETODOLAC TRANS-EMULGEL

Suchita A.Patil*, Dr. Surajj Sarode, Prof. B. S. Sathe, Dr. P. V. Jain
B. V. Jain, Dr. G.P. Vadnere

ABSTRACT

The aim of present research work was to investigate the possi- bility of dermal application of etodolac with emulgel formulations. Furthermore, the effect of different concentration of gelling agent, emulsifying agent and concentration of oil phase on the drug release, viscosity and spreadability was investigated and emulgel was optimized using 23 factorial design.The independent variables selected were carbopol 934,mixture of span 80 and tween 80,and liquid paraffin and dependent variables (responces)were cumulative amount of drug release across egg membrane in 8 hrs, viscosity and spreadability. Mathetical equations and response surface plots were used to relate dependent and independent variables and optimized formulation factors were selected. Emulgel formulations of Etodolac were prepared by using carbopol 934 as gelling agent, span 80 and tween 80 as emulsifiers and liquid paraffin as oil phase. Prepared emulgel were evaluated for their physical appearance, rheological studies, spreadability, pH values, drug content, in vitro drug release study, fitting of results into different kinetic equations, stability studies. The drug release was found to be higher for optimized formulation as compared to other formulations. Stability study showed that the physical appearance, rheological study, drug content, in vitro drug release study of optimized formulation remained unchanged upon storage condition for 3 months.

Keywords: Etodolac, oil phase, spreadability, pH values