Abstract

REVIEW ON HERBAL MEDICINES USED IN TREATMENT OF ANTIDIABETIC

Dhonde Satish Madhukar*, Hase Mayur Vasant, Gorde Pragati Shivaji, Ingale Shraddha Kailas, Jadhav Meghraj Dnyaneshwar and Ghumare Komal Laxman

ABSTRACT

Diabetes is a complex condition with a variety of causes and pathophysiology. The current single target approaches not provided ideal clinical outcomes for the treatment of the disease and its complications. Herbal medicine has been used for the management of various diseases such as diabetes over centuries. Many diabetic patients are known to use herbal medicines with anti-diabetic properties in addition to their mainstream treatments, which may present both a benefit as well as potential risk to effective management of their disease. In this review, we evaluate the clinical and experimental literature on herb–drug interactions in the treatment of diabetes. Pharmacokinetic and pharmacodynamic interactions between drugs and herbs are discussed, and some commonly used herbs which can interact with anti-diabetic drugs summarised. Herb–drug interactions can be a double-edged sword presenting both risks (adverse drug events) and benefits (through enhancement). There is a general lack of data on herb–drug interactions. As such, more rigorous scientific research is urgently needed to guide clinical practice as well as to safeguard the wellbeing of diabetes patients.

Keywords: Herb–drug interactions, Anti-diabetic drugs, Anti-diabetic herbs, Pharmacokinetic interaction, Pharmacodynamics interaction, Synergism.