Abstract

RULE OF PROBIOTICS CONTAINING INFANT FORMULA IN TREATMENT OF ACUTE DIARRHEA

Hala Qasim Raheem*, Douaa Mohammed Jameel and Ali Mansoor Shukur

ABSTRACT

Intestinal colonization of the neonate is highly dependent on the term of pregnancy, the mode of delivery, the type of feeding [breast feeding or formula feeding]. Postnatal immune maturation is dependent on the intestinal microbiome implementation and composition and type of feeding is a key issue in the human gut development, the diversity of microbiome, and the intestinal function. It is well established that exclusive breastfeeding for 6 months or more has several benefits with respect to formula feeding. The composition of the new generation of infant formulas aims in mimicking HM by reproducing its beneficial effects on intestinal microbiome and on the gut associated immune system (GAIS). Several approaches have been developed currently for designing new infant formulas by the addition of bioactive ingredients such as human milk oligosaccharides (HMOs), probiotics, prebiotics [fructo-oligosaccharides (FOSs) and galacto-oligosaccharides (GOSs)], or by obtaining the so-called post-biotics also known as milk fermentation products. The aim of this article is to guide the practitioner in the understanding of these different types of Microbiota Influencing Formulas by listing and summarizing the main concepts and characteristics of these different models of enriched IFs with bioactive ingredients. Methods: The total was 150 child from 30th of June 2019 to 30th of June 2021. Prospective study. Result: Show the table. Conclusion: The supports the use of prebiotics in infant formula for infants aged five months and older, as they have a more mature immune system. Aim: Triggered by the growing knowledge on the link between the intestinal microbiome and human health, the interest in probiotics is ever increasing. The authors aimed to review the recent literature on probiotics, from definitions to clinical benefits, with emphasis on children.

Keywords: Microbiome modifying formula; Probiotics; Prebiotics; Synbiotics; postbiotics; Human milk oligosaccharides; Diarrhea; Gastrointestinal infections.