Abstract

AMELIORATION OF CARRAGEENAN-INDUCED INFLAMMATION AND HYPOTHYROIDISM BY ETORICOXIB, A COX-2 INHIBITOR, IN RAT MODEL

Anand-Krishna Singh, Rayees-Ahmad Padder, Rameshwar Jatwa* and Anand Kar

ABSTRACT

The present study was premeditated to reveal the amelioration of carrageenan-induced inflammation and hypothyroidism by Etoricoxib, a selective COX-2 inhibitor, in Wistar rat model. Carrageenan was administered to induce paw edema and alteration in thyroid functions, glucose metabolism; lipid peroxidation (LPO) in hepatic; renal and cardiac tissues along with serum total cholesterol (TC) and highdensity lipoprotein cholesterol (HDL-C) levels in female Wistar rats were studied. Besides tissue glutathione content, alteration in body weight along with daily rate of food and water intake was also analyzed. Carrageenan administration on the hind footpad of rats significantly increased paw volume, tissue LPO, serum insulin, glucose and TG levels; it lowered circulating HDL-C level with a marked decline in the serum levels of T3 and T4 and daily rate of food and water consumption. While etoricoxib administration along with carrageenan treatment; status of all the thyroid dependent parameters was reversed with a consistent increase in circulating thyroid hormone levels. The findings of present study are suggestive that the drug might be acting through the restoration of thyroid homeostasis which in turn ameliorates inflammation and oxidative stress.

Keywords: lipid peroxidation (LPO); high-density lipoprotein cholesterol (HDL-C); total cholesterol (TC); thyroid hormones; oxidative stress.