Abstract

A REVIEW ON CO-AMORPHOUS SOLID DISPERSION

Ch Srilatha* and Sadhu Sridivya

ABSTRACT

Solubility is one of the major problems associated with many of the new chemicals that can be solved logically by changing drugs. However, as it is a highly potent form, crystals are often reintroduced, requiring new construction techniques to stabilize amorphous drugs. Polymeric amorphous solid dispersion (PASD) is one of the most widely investigated strategies for stabilizing amorphous materials, which has significant limitations such as moderate polymer melting and hygroscopicity. The Co amorphous system (CAM), which has recently entered the amorphous arena, is a promising form of PASD. CAMs are robust systems of a single amorphous component made up of two or more molecules that can be a combination of drugs or drugs and auxiliary substances. Materials tested for CAM preparation include amino acids, carboxylic acids, nicotinamide and saccharine. The benefits offered by CAM include improved fluid solubility and physiological stability of the amorphous drug, which has the potential to improve therapeutic efficacy. This review attempts to address various aspects of CAM development such as drug products. The condition of pre-selection, the various methods involved in CAM preparation, measurement tools, stability, advantages and disadvantages of solid co-amorphous dispersions and their limitations are discussed. Amorphous systems are expected to receive more attention in the pharmaceutical industry in the future, due to the growing number of people using non-soluble drugs. It is expected that the co-amorphous method of amorphous drug solidification may have the potential to stabilize the body and improve the elimination of insoluble drugs. Over the past few years, more than 35 research articles and 7 patents have been published in this area.

Keywords: Co-Amorphous solid dispersion, Crystalline, Recrystallization, Phase transition temperature, Stability, Co-formers, Amino Acids, Crystallinity.