Abstract

COMPARATIVE EVALUATION OF THE QUALITY MEASUREMENT OF SOME CIPROFLOXACIN HCL TABLETS MARKETED IN BANGLADESH

Fuad Laman*, Rahul Deb Chakraborty and Jannat Jahan Juthi

ABSTRACT

Ciprofloxacin is a second generation fluroquinolone antibiotics. In this research, Ciprofloxacin Hydrochloride of 500 mg tablets were randomly selected from three manufactures and has been assessed according to the the United States Pharmacopoeia. The following quality parameters were assessed: melting point, weight, thickness, friability, potency, stability, disintegration, dissolution tests and chemical content determination. The test of melting point, weight variation, length and width, thickness, the result of each brand from all of three brands maintained a pleasing result. Friability of the products is 0%, 0.232%, 0.380%. The average hardness of three brands exceeds the acceptable value. Brand of samples attained 80% dissolution within 30 minutes (83.521%, 81.713% and 83.811%) and shown a good dissolution profile. Assay of Ciprofloxacin tablets revealed that all sample contained labeled potency within the range (108.98%, 107.92%, and 106.86%). The potency of three brand is reduced after stability test. In-vivo bioavailability studies showed that three different brand of Ciprofloxacin HCl tablet meet the standards for physiochemical properties which indicates a drug with better quality.

Keywords: Friability, Dissolution, Absorbance, Standard Curve.