Abstract

PRELIMINARY EVALUATION: ANTISEIZURE POTENTIAL OF PARSONSIA STRAMINEA EXTRACTS USING MICE

Kemelayefa O. James*, Kamenebali Iyele and Tabowei Luther Ugochkwu

ABSTRACT

Introduction: The use of natural product for ill-health remedies is age long practice that is currently going through standardization; thus whatever product that is not orthodox including P.straminea all start from the preliminary stage of evaluation. Aim: The study is aimed at preliminary screening for safety and possible anti-seizure potential of P.straminea parts using ethanol for extraction. Method: The safety, toxicity and therapeutic potential of P.straminea with several study models involved among which are: LD50-toxicity, motor function, depression/anxiety, anti-seizure & phenobarbitone induced sleep. Results: The LD50 determination revealed that oral route of administration to be practically non-toxic contrary to i.p route with LD50 value of 2153 mg/kg ranking slightly toxic with evidence in the increase relative organ weight determination, motor-incoordination, depression and death record. However, the i.p indicated faster onset of action with ameliorating effect on the excitatory neurochemicals as evidenced in the bark part of P.straminea evaluation using PTZ,STC, & MES models independently. Additionally, the crude drug was also evaluated for sleeping time using phenobarbitone induced sleep with significant (P<0.001) decreased latency to sleep as evidence of non-sedating potential compared with controls. Conclusion: The ethanol extract of P.straminea has shown rapid onset of action with the i.p route of administration though considered slightly toxic via same route but practically non-toxic with the oral route. The bark part of the plant suggests anti-seizure potential in mice and anti-narcoleptic potential.

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